Detalhe da pesquisa
1.
Proteomic discovery of chemical probes that perturb protein complexes in human cells.
Mol Cell
; 83(10): 1725-1742.e12, 2023 05 18.
Artigo
Inglês
| MEDLINE | ID: mdl-37084731
2.
Remodeling oncogenic transcriptomes by small molecules targeting NONO.
Nat Chem Biol
; 19(7): 825-836, 2023 07.
Artigo
Inglês
| MEDLINE | ID: mdl-36864190
3.
Potent Phenylpyridine and Oxodihydrofuran Inhibitors of Cyclooxygenase-2: Optimization toward a Long Residence Time with Balanced Internal Energetics.
Biochemistry
; 60(31): 2407-2418, 2021 08 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34293856
4.
Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay.
Biochemistry
; 60(41): 3114-3124, 2021 10 19.
Artigo
Inglês
| MEDLINE | ID: mdl-34608799
5.
Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor.
J Pharmacol Exp Ther
; 372(3): 339-353, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31818916
6.
Mechanistic Characterization of Long Residence Time Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).
Biochemistry
; 57(51): 6997-7010, 2018 12 26.
Artigo
Inglês
| MEDLINE | ID: mdl-30422629
7.
Discovery of Inactive Conformation-Selective Kinase Inhibitors by Utilizing Cascade Assays.
Biochemistry
; 56(34): 4449-4456, 2017 08 29.
Artigo
Inglês
| MEDLINE | ID: mdl-28574701
8.
PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis.
J Pharmacol Exp Ther
; 353(2): 288-98, 2015 May.
Artigo
Inglês
| MEDLINE | ID: mdl-25698787
9.
Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling.
Biochemistry
; 52(51): 9187-201, 2013 Dec 23.
Artigo
Inglês
| MEDLINE | ID: mdl-24320749
10.
Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver.
J Lipid Res
; 53(5): 990-999, 2012 May.
Artigo
Inglês
| MEDLINE | ID: mdl-22394502
11.
Deconstruction of activity-dependent covalent modification of heme in human neutrophil myeloperoxidase by multistage mass spectrometry (MS(4)).
Biochemistry
; 51(10): 2065-77, 2012 Mar 13.
Artigo
Inglês
| MEDLINE | ID: mdl-22352991
12.
Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
J Med Chem
; 65(21): 14326-14336, 2022 11 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36314537
13.
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.
J Biol Chem
; 285(11): 8340-51, 2010 Mar 12.
Artigo
Inglês
| MEDLINE | ID: mdl-20061378
14.
Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.
J Pharmacol Exp Ther
; 338(1): 114-24, 2011 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-21505060
15.
Structure-guided inhibitor design for human FAAH by interspecies active site conversion.
Proc Natl Acad Sci U S A
; 105(35): 12820-4, 2008 Sep 02.
Artigo
Inglês
| MEDLINE | ID: mdl-18753625
16.
Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity.
ACS Med Chem Lett
; 12(5): 782-790, 2021 May 13.
Artigo
Inglês
| MEDLINE | ID: mdl-34055226
17.
Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation.
Cell Chem Biol
; 27(12): 1500-1509.e13, 2020 12 17.
Artigo
Inglês
| MEDLINE | ID: mdl-32888499
18.
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
J Med Chem
; 63(22): 13546-13560, 2020 11 25.
Artigo
Inglês
| MEDLINE | ID: mdl-32910646
19.
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).
Bioorg Med Chem Lett
; 19(10): 2865-9, 2009 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19386497
20.
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
J Med Chem
; 60(18): 7835-7849, 2017 09 28.
Artigo
Inglês
| MEDLINE | ID: mdl-28853885